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KMID : 0379520030190020141
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한국독성학회지
2003 Volume.19 No. 2 p.141 ~ p.146
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Mutagenicity Studies on Nonspecific Immunostimulator BARODON^{circledR}
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Seo Min-Su
Cho Sung-Dae
Ahn Nam-Shik
Jung Ji-Won
Yang Se-Ran
Park Joon-Suk
Park Ki-Su
Hong In-Sun
Jo Eun-Hye
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Abstract
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A nonspecific immunostimulator BARODON^{circledR} was tested for mutagenicity using Ames Salmonella tester strains TA98, TA1 00, TA 102, TA 1535 and TA 1537 with or without metabolic activation (59 mix). None of the fresh species showed mutagenicity. In the reverse mutation test using Salmonella phimurium TA98, TA100, TA102, TA1535 and TA1537 did not increase the number of revertants at all doses tested (5, 2.5 or 1.25 mg/ml). Chromosome aberration test was carried out in Chinese hamster lung (CHL) cell line. The cells were treated with BARODON^{circledR} (1, 0.5 or 0.25 mg/ml), while positive control group was treated with Mitomycin C (0.1 mg/ml). The results show that there is no statistically significant difference between positive control and treatment groups. In mouse micronucleus test, there was significant increase in the ratio of micronucleated polychromatic erythrocyte (MNPCE) in the high dose group (10% BARODON^{circledR}), while there is no significance between control and low (2.5% BARODON^{circledR}) or middle (5% BARODON^{circledR} dose groups. Taken together, this results suggest that below 5% BARODON^{circledR} might not have mutagenic potential in vitro and vivo systems.
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KEYWORD
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Mutagenicity, Ames test, Chromosome aberration, Micronucleus, BARODON^{circledR}, Immune-stimulator
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